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NAD+ as a signaling molecule modulating metabolism

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In several cellular compartments, either oxidized or reduced NAD serves in transhydrogenase reactions catalyzed by various oxidoreductase enzymes Houtkooper et al. They are ubiquitously expressed and share a conserved catalytic core of aminoacids. The diversity of sirtuin genes in mammals is associated with a specialization of their function and cellular localization. SIRT2 is mainly localized in the cytoplasm Michishita et al.

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